The Critical Care Nurse Research Program (CCRN) at the University of Virginia Health System has led to average 2. 25-fold reduction in major trauma-related deaths to children and adolescents resulting from care for gastrointestinal disorders spasm parenteral and colon cancers and sepsis and trials have demonstrated the programs efficacy in increasing survival rates to children and adolescents.

Using a randomly-chosen 14-person patient population a team of five Critical Care Nurse (CCN) physicians led the randomized clinical trial which analyzed the sequential outcomes of 13200 cesarean recipient children and adolescents admitted to acute care facilities between January 2006 and September 2012. In the eight-year follow-up period the average hospitalization for gastrointestinal disorders and the death rate to children and adolescents was 2. 77 per 1000 person-years compared to 3. 53 per 1000 person-years in the eight-year follow-up period for cancer: gastrointestinal colon and urological and urinary tract conditions less than or equal to 1. 25 cancer-related deaths per 1000 person-years.

The trial demonstrated three primary results:The trial was part of a groundbreaking collaboration between the UVAs Center for Child Health Well-being the Institute of Technology in Child Health the Ellison Family Foundation as well as the Foundation for Innovation in Critical Care. Through the collaboration the team was able to design a rigorous randomized clinical trial system which also used more evidence-based medical and child health outcomes subgroup analysis.

The average hospitalization time for gastrointestinal disorders among children and adolescents in the trial was 13. 2 months compared to 16. 1 months in the control group and 13. 2 months in the cancer-related death group compared to 11. 8 months in the control group.

The trial also established a baseline cohort of 38000 patients before they receive treatment to minimize the suboptimal number of people who are able to initiate or progress to complete the entire follow-up period and beyond.

We are very excited to see the improvement in outcomes seen in children and adolescents with gastrointestinal disorders and such acute cancers said AProf. Deanne Seneak MD who led the trial. Adapting a proven intervention and assessment method to an individuals needs is particularly challenging in clinical trials. The trial was funded by the National Institute of Health Research (R01-HL116874 and Netherlands Organization for Primary Care) and National Aeronautics and Space Administration (2P30ES02-CSI-17).