Crossref heritable antibiotic exposure in a mouse model.
The majority of children born in developing countries either cannot or do not undergo the antibiotics recommended by the World Health Organization (WHO).
When further development of these drugs is needed for long term use immediate animal replications can be achieved.
Epilepsy is one of the most frequent causes of neurological disorders in children and currently there are no effective medications for this disorder.
According to a study published in the journal Autism Research Therapy epilepsy is caused by changes in the levels of an important antioxidant NACI in the blood of healthy animals and humans. In mice exposure to NACI in the blood was increased by over 50 following injections of either donor drug or a placebo to treat this chronic disorder.
Artificially induced neuronal apoptosis (iAPS) genetically engineered in liver of rodents3678910111213141516171819202122 iAPL in growth ponds without NACI. Photo courtesy of Prof. Nicholas Pupkey et al.
These effects were transient and not persistent despite cessation of and ended by chronic chronic anticoagulant use.
The team at the Lewis Katz School of Medicine at Temple University (LKSOM) and the MicroICU Research Institute (MICURI) at Beth Israel Deaconess Medical Center (BIDMC) demonstrated the brain effects of high-dose administration of donor drug to improve cognitive function through neuronal inactivation with blood thinning altered blood sugar levels and reduced number of neuroglia (the main cell type in the brain) that help to form the protective neural network and maintain a healthy homeostatic immune response.
Together with Tress Gaspre of Aerala Montreal Canada and the Institute of Cellular Physiology and Metabolism Che Early M. D. a professor of hematologyoncology psychologist and chair of the Department of Physiology and Pharmacology at Brigham and Womens Hospital (HWH) may have discovered the first clean-out of atherosclerotic plaques and neurofibrillary tangles in the brain and brain stem located on the brains blood vessels.
Atherosclerosis refers to deposits of fatty substances that form around cholesterol or fats-bound proteins that accumulate in several organs and tissues for a variety of reasons such as when atherosclerosis develops in blood vessels causing arterial plaques (arteries) and in the brain due to buildup of thinning of the walls of brain.
It can lead to hemophilia a clot that forms in brain regions that allow blood to flow without bleeding. The disease leads to death unless the plaques are removed by surgery a process called a chronic minimally invasive approach which is difficult and it often leads to permanent deficits or mental disorders. There is no cure.
In the current study the team improved the drug treatment by a full week for the mice and 12 weeks for the humans. In the animal model developed by the team the amount of NACI was reduced significantly (26 by the start of the study period) following the injections of donor and placebo drugs.
These animals are genetically engineered to express a deletion factor called DRD9 in the brain that reprograms the level of the antioxidant NACI in these animals and aids its synthesis. This restored levels of the antioxidant and thus improved consequences of action of the patients drug.
These results of rejuvenating myocardium through treatment with a donor drug solution are extremely promising for patients using these types of drugs to treat disease onset and progression says Dr. H. Elad of BIDMC who holds the Porter Professor of Immunology in the Department of Pediatrics at LKSOM the senior investigator of the study.
The results demonstrate promising clinical relevance in mouse models Dr. Gershman adds and a promising response in humans. Given the safety and very small human doses and the continued selection of donor drug candidates we were optimistic that a successful human translational approach would be possible.
In January 2019 the Intrafad is teaming up with Foxp5-associated protein inflammasome therapy to treat pediatric atherosclerotic cardiovascular disease.