Some evidence suggests that the diabetes medications used to treat obesity may not be doing much to slow the appetites of patients who binge on sugary beverages.

After one binge people swig up to four or five glasses police reports and research indicate. And that may be troubling to those who detect such behavior and cannot control their cravings.

Those who binge or binge eating disorder report a compulsion – sometimes uncontrollable – to overeat according to eat-disorder experts at Mayo Clinic Mayo Clinic Rochester Minnesota.

The exact cause of binge eating or overeating is still unclear but emerging work suggests that its linked to changes in serotonin the brain chemical that aids weight maintenance.

In a new commentary in the journal JAMA Internal Medicine three physicians raise concerns that overeating may be a result of impairing neuroendocrine systems. That is there is a disconnect between a persons normal sense of hunger and appetite which can limit food intake and alter the way their brain processes sugar nutrients and other significant cues flood in causing them to seek more of these foods.

The researchers suggest they now understand a link between overeating and impaired serotonin transmission raising the prospect that efforts to combat the current health crisis will need to include efforts to regulate serotonin levels in the brain.

The researchers generated healthy obese at-risk participants who ate three to eight times the recommended three meals per day. A second group of similarly challenged participants ate no more than two meals per day.

During a mean of 18. 4 months participants bingeed on an average of four to seventeen servings a day according to a 2013 meta-analysis published in The Journal of Obesity.

In that study a highly rated condition was only diagnosed in one adult participant – and with bingeing disorder that patient was four times more likely to be diagnosed.

Its the third time this series of studies has occurred for sciences digital equivalent of the American Heart Association: the Mayo Clinic Brain Health Initiative a web-based program funded by the National Institutes of Health.

Its really good news when youre raising millions of dollars for the big law said Jeanne C. Pockliff who chairs the Mayo Clinic Brain Health Initiative and was not involved in the study.

Brain health she said is based above and above on the individuals ability to manage his or her glucose utilization and energy balance which assuredly can be improved with lifestyle and environmental changes including what diets include and which foods grow nutrients from the inside out.

Biologically speaking microbes belonging to the gut are shaping the brain. And one of the key chemicals in the gut is serotonin.

Serotonin is involved in the brain function of patients with eating disorders and the gut microbiome is probably important in those decisions Pockliff said. It could be an adaptive factor for them or it could also be an environmental structural thing.

And the diminished appetite is a collective effort she said. Although there may be factors involved in general the same person feels less hungry and may ignore his or her diet.

Exercise and changes diet can counteract overeating Anderson believes including with exercise. Also the work shows how obesity diabetes and obstructive sleep apnea – a sleep-disrupting sleep disorder that can also cause chronic hunger – can all reduce food intake to some degree both in the body and brain.

For her current study–which judges brain effects through positron emission tomography (PET) scan of the brain–the Mayo Clinic researchers recruited female volunteers and scheduled them to eat a normal diet increase their watching sugar levels in their blood and switch to bottles of Ensure-brand bottled water.

During a follow-up of around three years the group showed a satiety index (i. e. how many calories the subjects ate) of 14. 81.

But a second set of people did not meet the criteria for the high group of the study at 13. 57 and 14. 84 respectively.

We were uncomfortable with these results because they were derived from a very small number of people said Christine R. OMalley a toxicologist at Mayo Clinic and the studys lead author.

OMalley who wasnt involved in the study said more studies are needed to determine the long-term impact of these findings on people who binge eat binge on sugar and resort to excessive food intake.

Some previous research on one form of binge eating show someone may not feel the same way for prolonged periods.