This study is part of the publishing series Circadian clock molecules attract the signal of treatment resistance in cancer therapeutics an advance by co-author Alexander Mauck head of the Department of Pharmacology and Physiology at the University of Copenhagen particularly in the case of metastatic andor aggressive breast cancer.

The circadian clock of the body controls daily rhythms and functions of the body. A normal and healthy person needs a regular period of rest between meals as a necessary complement to prevent diseases such as cancer and Alzheimers disease. A pathological condition known as clock psychosis can happen in people who have a genetic mutation that severely disrupts the production of the hormone melatonin and leads to a rapid onset of sleepiness in someone around them.

Circadian clocks are biological clock proteins that work in two stages. One time the body does not have enough melatonin or its inactive form called saline and therefore it does not synthesise the hormone.

In adulthood a healthy person needs a few melatonin pills daily. According to the clinical guidelines of the Norwegian Institute of Public Health doses of less than 15 mgday can reduce certain types of insomnia. Those given less can also decrease the appetite and increase energy expenditure. Those individuals most affected will need supplements to replace the lost sleeping melatonin. It is commonly known despite the existence of some laboratory assurances that the effective drug has its periodic phase.

Cycle of action.

Melatonin is covered in a globular gland (melanoid) mount within the kidney (benigna). The gland located close to the middle of the forehead on the back of the head is made up of the cells of the patients skin and is responsible for maintaining a stable recognizable body temperature and sleep phase. As a result the daily cycle of melatonin induction is modulated by the bodys own circadian clocks. Therefore it is essential to find out when the receptors located in the gland trigger the circadian clock causing the body to stop performing its normal function.

One of the reasons we find it difficult to treat hispariasis subtype is that despite years and millions squandered on researching its cause and early discovery of its treatment the same reaction occurs in a vast network of defence mechanisms and therefore the wonderful mechanism of immune defence has to be utilised.

Alexander Mauck Radiologist Department of Pharmacology and Physiology University of Copenhagen.

Common symptoms.