A protein that helps adult healthy heart cells get established and healthy has been identified by scientists from Trinity College Dublin.
The protein Lamin A (npp) assists with the development of adult cardiac muscle cells (cardiomyocytes) a crucial component of the developing heart.
The study led by Trinity scientists Trinity Biomedical Sciences and genetics fellow Finnegan University could potentially benefit patients undergoing procedures to repair heart muscle such as heart transplants.
We first identified Lamin A as a protein kinase which helps adult cardiac development by regulating the protein levels in adult cells by reducing the production of factors such as angiotensin II that trigger contraction and irregular heartbeats.
Dr. Mark Lynas senior author professor in the Trinity Sex and Ageing Research Unit at Trinity.
These findings were published in Biochemical and Biophysical Research Communications.