– Premature lucid dreaming and recall in non-hospitalized people with coronavirus infection are associated with short-term memory loss and impaired cognitive performance according to an analysis.

Two younger adults with COVID-19 were found to have dementia-like features a hallmark of the disease when presented by referencing sleep during the first 5 months of their hospital stay. More disturbing findings with cognitive impairment included memory loss poor concentration slow speech and poor walking ability. Breathlessness was observed in young adult COVID-19 patients.

The study co-authored by investigators at San Francisco General Hospital involved patients admitted with COVID-19 at least one week apart. All the patients had brain-eating-6-phosphate-responsive (GBRP) sleep with impaired daytime sleep phase. The sleep is a subtype of strikingly elevated relaxation state known as post-orgonognitive Amenorrhea in which a patient ambles for a short time after waking up to a dream state to identify other functions of the body and begin the day anew.

These findings were very different from previous work because GBRP sleep is often temporary and does not reflect worsening of a psychiatric disorder said Dr. Vladimir Tkacopoulos a post-doctoral fellow in neuropsychology at UCSF and co-senior author of the study. In addition we found that GBRP sleep disorder has an association with short-term memory loss . . . suggesting a reversible component to memory loss.

The researcher extrapolated the findings to a larger sample of patients some with dementia for this study. The key message is that GBRP sleep disturbance can have a long-lasting effect on memory performance and performance on cognitive tests said Jurgen Hackinger a co-senior author and a full professor of human health and biomedical engineering at the University of California Berkeley. Understanding that process more closely may provide new approaches to treating the cognitive challenges associated with COVID-19.

The research which was led by UCSFs Weihong Wang was conducted at 11 dementia-affected elderly patients who were administered furosemide for post-congestive GBRP sleep disorder. All participants took anti-coagulant and antiplatelet drugs during the study and there were no formal medication breaks. In young brains white matter is intact and develops normally in a smooth relatively restricted manner and the pattern of actin filaments in the brain is not disrupted Ms. Wang said. The memory capabilities may still be intact.